Effect of serum from dogs with renal failure on apoptosis and oxidative metabolism of polymorphonuclear

Authors

  • Tatiane de Sousa Barbosa
  • Carolina Kimie Mori
  • Paulo César Ciarlini

Keywords:

Burst respiratory, Programmed cell death, Leukocyte, Superoxide.

Abstract

In recent years, uremic toxins have been widely investigated as an immunosuppressive factor for nephropathic patients. This study aimed to test the hypothesis that, as it was similarly observed in humans, the rate of apoptosis and superoxide production in polymorphonuclear leukocytes are changed in dogs treated with uremic serum. The superoxide production of polymorphonuclear leukocytes and apoptotic index of 10 healthy dogs incubated with autologous and homologous serum from healthy and uremic dogs was compared. Thus, there was an effect of partial inhibition of oxidative metabolism in uremia without correlation with the acceleration of polymorphonuclear leukocytes apoptosis in dogs.

Downloads

Download data is not yet available.

Downloads

Published

2015-02-11

How to Cite

BARBOSA, Tatiane de Sousa; MORI, Carolina Kimie; CIARLINI, Paulo César. Effect of serum from dogs with renal failure on apoptosis and oxidative metabolism of polymorphonuclear. Revista de Ciências Agroveterinárias, Lages, v. 13, n. 3, p. 302–309, 2015. Disponível em: https://revistas.udesc.br/index.php/agroveterinaria/article/view/5702. Acesso em: 23 nov. 2024.

Issue

Vol. 13 No. 3 (2014)

Section

Research Article - Science of Animals and Derived Products

License

Authors publishing in this journal are in agreement with the following terms:

a) Authors maintain the copyrights and concede to the journal the copyright for the first publication, according to Creative Commons Attribution Licence.

b) Authors have the authority to assume additional contracts with the content of the manuscript.

c) Authors may supply and distribute the manuscript published by this journal.

Most read articles by the same author(s)