The veterinary medicinal products market supply gap: A practical insight based on the Regulation (EU) 2019/6




medical prescription, pharmacology, pharmacy, veterinarian, therapeutics


The Regulation (EU) 2019/6 establishes that the veterinary prescriptions should follow a cascade, according to their availability of the market. In sum, the veterinarian is authorized to use a medicine for human use only if there is no product available for the same or other therapeutic indication, in the same or another animal species. This study aims to analyse the application of Regulation (EU) 2019/6 in the pharmacological prescription at the Veterinary Hospital of the University of León. A total of 121 clinical cases, 89 dogs (73.55%) and 32 cats (26.45%) were included. Results revealed that 95 medicines were prescribed, 51 (53.68 %) as veterinary medicines and 44 (46.32 %) as human medicines. From the human medicines, 22 (50.00%) did not have a veterinary alternative in the market; four (9.00%) presented a veterinary medicine in the appropriate formulation for the species; 10 (23.00%) had no alternative in the desired formulation; and 8 (18.00%) had no alternatives for the target species. This study suggested that the cascade was not strictly followed, and several reasons may justify it, such as the lack of veterinary products, different formulations, and differences in costs. An effective, safe and sustainable use of the therapeutic option available can only be accomplished with a rational use of the prescription cascade and a correct use of the Regulation (EU) 2019/6.


Download data is not yet available.

Author Biographies

Rafaela Nogueira, Department of Veterinary Sciences, University of Trás-os-Montes and Alto Douro (UTAD), Vila Real, Portugal


Catarina Jota Baptista, Centre for the Research and Technology of Agro-Environmental and Biological Sciences (CITAB), Inov4Agro, UTAD, Vila Real Portugal


Lio Gonçalves, Department of Engineering, UTAD, Vila Real, Portugal


Ana Claúdia Coelho, Associate Laboratory for Animal and Veterinary Sciences (AL4AnimalS), Lisbon, Portugal;


Ana I. Faustino-Rocha, Department of Zootechnics, School of Sciences and Technology, University of Évora, Évora, Portugal


Marta Regueiro Purriños, Hospital Veterinario, Universidad de León, Léon, Spain.


José M. Gonzalo-Orden, Instituto de Biomedicina (IBIOMED), Universidad de León, León, Spain.


Paula A. Oliveira, Department of Veterinary Sciences, University of Trás-os-Montes and Alto Douro (UTAD), Vila Real, Portugal



BEYENE T & TESEGA B. 2014. Rational veterinary drug use: Its significance in public health. Journal of Veterinary Medicine and Animal Health 6: 302-308.

BOLLER M. 2021. When money means a life-or-death choice for our dogs by Stuart Winthrope (University of Melbourne). Animals, Food and You.

ELWOOD C et al. 2010. Emesis in dogs: a review. Journal of Small Animal Practice 51: 4–22.

EUROPEAN MEDICINES AGENCY. 2023. What we do - European Medicines Agency [WWW Document]. European Medicines Agency.

GRUEN ME et al. 2022. 2022 AAHA Pain Management Guidelines for Dogs and Cats. JAAHA 58: 55–76.

HARDEE G & BAGGOT J. 2019. Development and formulation of veterinary dosage forms. 2.ed. Boca Raton: CRC Press.

LANUSSE M. 2021. Importance of veterinary drugs. Advances in Animal Science, Theriogenology, Genetics and Breeding 9: 9-10.

NEWMAN M. 2018. Drug companies are incentivised to profit not to improve health, says report. BMJ 363: k4351.

NOGUEIRA R. 2023. Terapias Instituídas em Animais de Companhia: aplicação do Regulamento (UE) 2019/6. (Master Thesis). Vila real: University of Trás-os-Montes and Alto Douro.

REGULATION EU 2019/6. 2018. Regulation EU 2019/6 of the European Parliment and Council. Official Journal of the European Union L/4.43.

UNIVERSIDAD DE LEÓN. 2023. Universidad de León - Hospital Veterinario [WWW Document].

UNIVERSIDAD DE LEÓN. 2020. Hospital Veterinario de la Universidad de León, Unileón en positivo.

VAN NORMAN GA. 2019. Limitations of Animal Studies for Predicting Toxicity in Clinical Trials. JACC Basic Transl Sci 4: 845–854.

WINZENBURG G et al. 2004. Biodegradable polymers and their potential use in parenteral veterinary drug delivery systems. Adv Drug Deliv Rev 56: 1453–1466.




How to Cite

NOGUEIRA, Rafaela; BAPTISTA, Catarina Jota; GONÇALVES, Lio; COELHO, Ana Claúdia; FAUSTINO-ROCHA, Ana I.; PURRIÑOS, Marta Regueiro; GONZALO-ORDEN, José M.; OLIVEIRA, Paula A. The veterinary medicinal products market supply gap: A practical insight based on the Regulation (EU) 2019/6. Revista de Ciências Agroveterinárias, Lages, v. 23, n. 1, p. 153–158, 2024. DOI: 10.5965/223811712312024153. Disponível em: Acesso em: 22 jul. 2024.



Review Article - Science of Animals and Derived Products

Funding data