Effect of serum from dogs with renal failure on apoptosis and oxidative metabolism of polymorphonuclear

Authors

  • Tatiane de Sousa Barbosa
  • Carolina Kimie Mori
  • Paulo César Ciarlini

Keywords:

Burst respiratory, Programmed cell death, Leukocyte, Superoxide.

Abstract

In recent years, uremic toxins have been widely investigated as an immunosuppressive factor for nephropathic patients. This study aimed to test the hypothesis that, as it was similarly observed in humans, the rate of apoptosis and superoxide production in polymorphonuclear leukocytes are changed in dogs treated with uremic serum. The superoxide production of polymorphonuclear leukocytes and apoptotic index of 10 healthy dogs incubated with autologous and homologous serum from healthy and uremic dogs was compared. Thus, there was an effect of partial inhibition of oxidative metabolism in uremia without correlation with the acceleration of polymorphonuclear leukocytes apoptosis in dogs.

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Published

2015-02-11

How to Cite

BARBOSA, Tatiane de Sousa; MORI, Carolina Kimie; CIARLINI, Paulo César. Effect of serum from dogs with renal failure on apoptosis and oxidative metabolism of polymorphonuclear. Revista de Ciências Agroveterinárias, Lages, v. 13, n. 3, p. 302–309, 2015. Disponível em: https://revistas.udesc.br/index.php/agroveterinaria/article/view/5702. Acesso em: 26 dec. 2024.

Issue

Vol. 13 No. 3 (2014)

Section

Research Article - Science of Animals and Derived Products

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